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後天的な遺伝子疾患

後天的な遺伝子発現と病気と治療 [BioToday]

後成的機構は、遺伝子配列自体は変更しないもののDNAやヒストンタンパク質の変更によって遺伝子発現が抑制される機構です。これまで、ヒトの病気の原因解明は主に遺伝子変異にスポットが当てられてきました。
たしかに遺伝子疾患というと「生まれ持ったもの」というイメージが強くありますね。 でも後天的に遺伝子を読み取る装置や遺伝子を格納している装置に不具合が出てくることでおこる遺伝子疾患もあり、これからは後天的な遺伝子疾患の研究が進んでいくだろうという報告です。
現在確認されている後天的な疾患のうち、後天性の遺伝子疾患が占める割合がどのくらいあるのでしょうね。 まずは後天的遺伝子疾患を同定していくという方向で研究が進んでいくのかな?

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